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Amiloride is a drug used in the treatment of high blood pressure and heart disease.

Early research suggested that the drug may have a neuroprotective effect in multiple sclerosis by reducing the levels of calcium and sodium that were able to pass through the nerve cell membrane and damage the axons.

Results of a pilot study in 12 people with primary progressive MS were reported in 2013. Although the numbers involved in the trial were too small to make definitive conclusions, participants experienced less damage to nerves, loss of brain volume and a slower change in EDSSwhilst taking the drug than in the year before treatment.

Amiloride is one of three drugs being studied by the phase II MS-SMART trial, which will involve 440 people with secondary progressive MS.

Last updated: November 2017
Last reviewed: February 2015
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