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A to Z of MS Low dose naltrexone (LDN)

Naltrexone (Nalorex) is a drug used to treat people with addictions. There are anecdotal reports that low doses help the symptoms of people with a wide range of conditions, including cancer, AIDS and MS.

Although no research into LDN and MS has been published in the medical literature as yet, there are several ongoing trials involving LDN and MS. Initial results of these are expected during 2008.

How LDN works

It is thought that LDN works by encouraging the body to produce endorphins and by stimulating the immune system - an approach that differs from most MS treatments, which attempt to reduce immune activity.

How LDN is given

LDN is taken orally either as capsules or in a liquid form.

Side effects and contraindications

Although there is anecdotal support for the treatment, there is as yet no independent verification of the efficacy and safety of LDN in the treatment of MS.

The full strength drug should not be used in conjunction with an opioid-containing medication or with people with hepatitis or liver problems. Anecdotally, the low dose treatment is associated with few or no side effects.

Because LDN stimulates the immune system, it should not be taken by people also taking one of the beta interferon drugs or other drugs that reduce immune system activity such as steroids.

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