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MS research update - Improving relapse care - 26 April 2012

This study compared the experiences of people being treated for a relapse either as part of a clinical trial or within the standard out-patient service.

Both groups received identical treatment - intravenous infusion of steroid (methylprednisolone) for three days. The two groups completed questionnaires to measure their experience of treatment, answering questions under four headings: interpersonal care, access to care, information and coordination of care.

Interpersonal care was significantly worse in the out-patient group, implying that a clinical trial in some way provided a setting that improved this aspect of relapse management.

The researchers suggest that this may be a result of the study design, of the care given or changes in behaviour of patients and/or health professionals while taking part in the study. They recommend incorporating elements of structured clinical trials into routine practice in order to provide a more person-centred service for the treatment of relapses.

McNicholas N, Patel A, Chataway J., et al.
It is better to be in a clinical trial than not: lessons learnt from clinical neurology - the management of acute multiple sclerosis relapses.
QJM. 2012 Apr 17. [Epub ahead of print]

Research by topic areas...


Maalouly G, Mantout F, Feldman-Billard S, et al.
Oligoclonal band and multiple sclerosis risk in monosymptomatic optic neuritis patients: a retrospective study of 84 patients.
Mult Scler. 2012 Apr 18. [Epub ahead of print]

Mattarozzi K, Vignatelli L, Baldin E, et al.
Effect of the disclosure of MS diagnosis on anxiety, mood and quality of life of patients: a prospective study.
Int J Clin Pract. 2012 May;66(5):504-514. doi: 10.1111/j.1742-1241.2012.02912.x.

Symptoms and symptom management

Pozzilli C, Schweikert B, Ecari U, et al.
Quality of life and depression in multiple sclerosis patients: longitudinal results of the BetaPlus study.
J Neurol. 2012 Apr 18. [Epub ahead of print]

Hartung HP.
Advances in the management of multiple sclerosis-related spasticity.
Expert Rev Neurother. 2012 Apr;12(4 Suppl):1.

Moss-Morris R, McCrone P, Yardley L, et al.
A pilot randomised controlled trial of an Internet-based cognitive behavioural therapy self-management programme (MS Invigor8) for multiple sclerosis fatigue.
Behav Res Ther. 2012 Mar 13;50(6):415-421. [Epub ahead of print]

Xiao Y, Wang J, Luo H.
Sildenafil citrate for erectile dysfunction in patients with multiple sclerosis.
Cochrane Database Syst Rev. 2012 Apr 18;4:CD009427.

Gal RL, Vedula SS, Beck R.
Corticosteroids for treating optic neuritis.
Cochrane Database Syst Rev. 2012 Apr 18;4:CD001430.

Jongen PJ, Ter Horst AT, Brands AM.
Cognitive impairment in multiple sclerosis.
Minerva Med. 2012 Apr;103(2):73-96.

Disease modifying treatments

Chiba K, Adachi K.
Discovery of fingolimod, the sphingosine 1-phosphate receptor modulator and its application for the therapy of multiple sclerosis.
Future Med Chem. 2012 Apr;4(6):771-81.

Bischoff C, Schreiber H, Bergmann A.
Background information on multiple sclerosis patients stopping ongoing immunomodulatory therapy: a multicenter study in a community-based environment.
J Neurol. 2012 Apr 18. [Epub ahead of print]

Lanzillo R, Bonavita S, Quarantelli M, et al.
Natalizumab is effective in multiple sclerosis patients switching from other disease modifying therapies in clinical practice.
Neurol Sci. 2012 Apr 22. [Epub ahead of print]

Hauser SL, Johnston SC.
Multiple sclerosis drugs: Sticker shock.
Ann Neurol. 2012 May;71(5):A5-6. doi: 10.1002/ana.23608.

Balcer LJ, Galetta SL, Polman CH, et al.
Low-contrast acuity measures visual improvement in phase 3 trial of natalizumab in relapsing MS.
J Neurol Sci. 2012 Apr 20. [Epub ahead of print]

Bignardi D, Ribizzi G, Voltolini S, et al.
Successful desensitization to natalizumab in a skin test--positive patient: a case report.
Eur Ann Allergy Clin Immunol. 2012 Feb;44(1):26-9.

Gheuens S, Smith DR, Wang X, et al.
Simultaneous PML-IRIS after discontinuation of natalizumab in a patient with MS.
Neurology. 2012 Apr 18. [Epub ahead of print]

Drugs in development

Liu J, Wang L, Zhan SY, et al.
Daclizumab for relapsing remitting multiple sclerosis.
Cochrane Database Syst Rev. 2012 Apr 18;4:CD008127.

Other treatments

Wade D.
Evaluation of the safety and tolerability profile of Sativex(®): is it reassuring enough?
Expert Rev Neurother. 2012 Apr;12(4 Suppl):9-14.

Oreja-Guevara C.
Clinical efficacy and effectiveness of Sativex(®), a combined cannabinoid medicine, in multiple sclerosis-related spasticity.
Expert Rev Neurother. 2012 Apr;12(4 Suppl):3-8.


Jackson K, Edginton-Bigelow K, Bowsheir C, et al.
Feasibility and effects of a group kickboxing program for individuals with multiple sclerosis: a pilot report.
J Bodyw Mov Ther. 2012 Jan;16(1):7-13. Epub 2010 Sep 29.

Co-existing conditions

Mullen AE, Wilmarth MA, Lowe S.
Cervical Disk Pathology in Patients With Multiple Sclerosis: Two Case Reports.
Phys Ther. 2012 Apr 19. [Epub ahead of print]

Assessment tools

Jacobs JV, Kasser SL.
Balance impairment in people with multiple sclerosis: Preliminary evidence for the Balance Evaluation Systems Test.
Gait Posture. 2012 Apr 21. [Epub ahead of print]

Cohen JA, Reingold SC, Polman CH, et al.
Disability outcome measures in multiple sclerosis clinical trials: current status and future prospects.
Lancet Neurol. 2012 May;11(5):467-476.

Phan-Ba R, Calay P, Grodent P, et al.
Motor fatigue measurement by distance-induced slow down of walking speed in multiple sclerosis.
PLoS One. 2012;7(4):e34744. Epub 2012 Apr 13.
free full paper

Livshits I, Hussein S, Kennedy C, et al.
Comparison of a 1.5T standard vs. 3T optimized protocols in multiple sclerosis patients.
Minerva Med. 2012 Apr;103(2):97-102.

Causes of MS

Disanto G, Morahan JM, Barnett MH, et al.
The evidence for a role of B cells in multiple sclerosis.
Neurology. 2012 Mar 13;78(11):823-32.

Vitamin D

Schwalfenberg GK.
Solar radiation and vitamin d: mitigating environmental factors in autoimmune disease.
J Environ Public Health. 2012;2012:619381.
free full paper

Paediatric MS

Kornek B, Schmitl B, Vass K, et al.
Evaluation of the 2010 McDonald multiple sclerosis criteria in children with a clinically isolated syndrome.
Mult Scler. 2012 Apr 23. [Epub ahead of print]

Absoud M, Lim MJ, Chong WK, et al.
Paediatric acquired demyelinating syndromes: incidence, clinical and magnetic resonance imaging features.
Mult Scler. 2012 Apr 19. [Epub ahead of print]


Baranzini SE, Nickles D.
Genetics of multiple sclerosis: swimming in an ocean of data.
Curr Opin Neurol. 2012 Apr 18. [Epub ahead of print]

Other demyelinating conditions

Chan JW.
Early diagnosis, monitoring, and treatment of optic neuritis.
Neurologist. 2012 Jan;18(1):23-31.

Provision of care

Skovgaard L, Bjerre L, Haahr N, et al.
An investigation of multidisciplinary complex health care interventions - steps towards an integrative treatment model in the rehabilitation of People with Multiple Sclerosis.
BMC Complement Altern Med. 2012 Apr 23;12(1):50. [Epub ahead of print]


Blinkenberg M, et al.
Chronic cerebrospinal venous insufficiency and venous stenoses in multiple sclerosis.
Acta Neurol Scand. 2012 Apr 25. doi: 10.1111/j.1600-0404.2012.01671.x. [Epub ahead of print]

Simka M, Ludyga T, Latacz P, et al.
Diagnostic accuracy of current sonographic criteria for the detection of outflow abnormalities in the internal jugular veins.
Phlebology. 2012 Apr 23. [Epub ahead of print]

Amato M, Saia V, Hakiki B, et al.
No association between chronic cerebrospinal venous insufficiency and pediatric-onset multiple sclerosis.
Mult Scler. 2012 Apr 18. [Epub ahead of print]

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