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MS research update - Migraine more likely in MS - 03 October 2012

A migraine is a severe headache usually felt as a throbbing pain at the front or on one side of the head but it can be accompanied by nausea and sensitivity to light. It is common in the general population, affecting about one in seven people. People with MS can experience a wide range of symptoms but migraine is not usually considered to be one of them.

People who have MS and people who experience migraines have several things in common: they are more likely to be women, more likely to be relatively young when symptoms begin and more likely to be from Caucasian rather than African or Asian populations.

Previous research looking at the number of people with MS who also experienced migraines, had found a wide range of results. This study was a meta-analysis which combined the results from previous studies as long as they met certain criteria. These were: case-control study or cohort study; migraine specified as a subtype of headache; other neurological conditions excluded from controls; published in English.

Eight studies met the criteria and, in total, they included 1,864 people with MS and 261,563 controls. The analysis found that migraine was more than twice as common in people with MS than it was in controls. The authors suggest that migraine may be more common in MS than previously realised and may contribute to a reduced quality of life. Consequently, it may be important for clinicians to actively look for and treat migraine in people with MS.

Pakpoor J, Handel AE, Giovannoni G, et al.
Meta-analysis of the relationship between multiple sclerosis and migraine.
PLoS One. 2012;7(9):e45295.
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More about migraine

You can read more about migraine on the NHS Choices web site.  

Research by topic areas...

Symptoms and symptom management

Labuz-Roszak B, Kubicka-Bączyk K, Pierzchała K, et al.
Fatigue and its association with sleep disorders, depressive symptoms and anxiety in patients with multiple sclerosis.
Neurol Neurochir Pol. 2012;46(4):309-317.

Dillon BE, Seideman CA, Lee D, et al.
A surprisingly low prevalence of demonstrable stress urinary incontinence and pelvic organ prolapse in women with multiple sclerosis followed at a tertiary neurogenic bladder clinic.
J Urol. 2012 Sep 25. pii: S0022-5347(12)04998-1. doi: 10.1016/j.juro.2012.09.101. [Epub ahead of print]

Disease modifying treatments

Yildiz M, Tettenborn B, Borgwardt S.
Trajectory of fatigue severity in natalizumab treated multiple sclerosis patients.
Clin Neurol Neurosurg. 2012 Sep 26. pii: S0303-8467(12)00478-7. doi: 10.1016/j.clineuro.2012.08.039. [Epub ahead of print]

Wickström A, Nyström J, Svenningsson A.
Improved ability to work after one year of natalizumab treatment in multiple sclerosis. Analysis of disease-specific and work-related factors that influence the effect of treatment.
Mult Scler. 2012 Sep 25. [Epub ahead of print]

Other treatments

Kale N.
Management of optic neuritis as a clinically first event of multiple sclerosis.
Curr Opin Ophthalmol. 2012 Sep 24. [Epub ahead of print]

Co-existing conditions

Alkhawajah MM, Caminero AB, Freeman HJ, et al.
Multiple sclerosis and inflammatory bowel diseases: what we know and what we would need to know!
Mult Scler. 2012 Oct 1. [Epub ahead of print]

Assessment tools

Zhang J, Waubant E, Cutter G, et al.
EDSS variability before randomization may limit treatment discovery in primary progressive MS.
Mult Scler. 2012 Oct 1. [Epub ahead of print]

Sormani M, Rio J, Tintorè M, et al.
Scoring treatment response in patients with relapsing multiple sclerosis.
Mult Scler. 2012 Sep 25. [Epub ahead of print]

Prosperini L, Giannì C, Barletta V, et al.
Predictors of freedom from disease activity in natalizumab treated-patients with multiple sclerosis.
J Neurol Sci. 2012 Sep 21. pii:S0022-510X(12)00479-0. doi: 10.1016/j.jns.2012.08.027. [Epub ahead of print]

Paediatric MS

Arnal-Garcia C, García-Montero MR, Málaga I, et al.
Natalizumab use in pediatric patients with relapsing-remitting multiple sclerosis.
Eur J Paediatr Neurol. 2012 Sep 26. pii: S1090-3798(12)00196-1. doi: 10.1016/j.ejpn.2012.09.004. [Epub ahead of print]


Jonzon AJ, Goodwin DL.
Daughters of mothers with multiple sclerosis: their experiences of play.
Adapt Phys Activ Q. 2012 Jul;29(3):205-23.

Psychological aspects

Kiiski H, Reilly RB, Lonergan R, et al.
Only low frequency event-related EEG activity is compromised in multiple sclerosis: insights from an independent component clustering analysis.
PLoS One. 2012;7(9):e45536.

Physical activity

Hale LA, Mulligan HF, Treharne GJ, et al.
The feasibility and short-term benefits of Blue Prescription: a novel intervention to enable physical activity for people with multiple sclerosis.
Disabil Rehabil. 2012 Oct 1. [Epub ahead of print]

Jensen MP, Molton IR, Gertz KJ, et al.
Physical activity and depression in middle and older-aged adults with multiple sclerosis.
Disabil Health J. 2012 Oct;5(4):269-76. doi: 10.1016/j.dhjo.2012.05.006.

Kasser SL, Kosma M.
Health beliefs and physical activity behavior in adults with multiple sclerosis.
Disabil Health J. 2012 Oct;5(4):261-8. doi:10.1016/j.dhjo.2012.07.001.


Lindsey JW, Khan U, Ansari W, et al.
The antibody response to Epstein-Barr virions is altered in multiple sclerosis.
J Neuroimmunol. 2012 Sep 28. pii: S0165-5728(12)00280-9. doi:10.1016/j.jneuroim.2012.09.007. [Epub ahead of print]

Schoonheim MM, Popescu V, Rueda Lopes FC, et al.
Subcortical atrophy and cognition: Sex effects in multiple sclerosis.
Neurology. 2012 Sep 26. [Epub ahead of print]

Fisher E, Benedict RH.
Correlation of cognitive impairment and thalamic atrophy in MS: For men only?
Neurology. 2012 Sep 26. [Epub ahead of print]


Plow M, Finlayson M, Cho C.
Correlates of nutritional behavior in individuals with multiple sclerosis.
Disabil Health J. 2012 Oct;5(4):284-91.

Ng A, Kennedy P, Hutchinson B, et al.
Self-efficacy and health status improve after a wellness program in persons with multiple sclerosis.
Disabil Rehabil. 2012 Sep 25. [Epub ahead of print]

Bone health

Moen SM, Celius EG, Sandvik L, et al.
Bone turnover and metabolism in patients with early multiple sclerosis and prevalent bone mass deficit: a population-based case-control study.
PLoS One. 2012;7(9):e45703.

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