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MS research update - Vitamin D3 supplements tested in people with MS - 29 February 2012

Vitamin D has several important roles in the body including regulating immune responses. It is thought that high vitamin D levels may reduce the risk of relapses and disease progression in MS but this is the subject of much debate.

This research project aimed to test this idea using supplements of vitamin D3, the form of vitamin D that is made naturally in the skin by sunlight.

68 people were divided into two groups and one group was given 20,000 International Units of vitamin D3 per week. This is approximately seven times the current daily recommended intake for the UK. Participants were aged 21 to 50 and were fully mobile (EDSS score averaged 2.5).

After 96 weeks (nearly 2 years), there was no difference between the relapse rate of the two groups. There was also no difference between their EDSS scores, overall abilities, grip strength or fatigue levels.

The researchers concluded that this level of supplementation with vitamin D was of no benefit to people with MS who were fully mobile.

You can read more about vitamin D in the A-Z of MS. 

Kampman MT, Steffensen LH, Mellgren SI, et al.
Effect of vitamin D3 supplementation on relapses, disease progression and measures of function in persons with multiple sclerosis: exploratory outcomes from a double-blind randomised controlled trial.
Mult Scler. 2012 Feb 21. [Epub ahead of print]
abstract

Research by topic areas...

Disease modifying treatments

Saida T, Kikuchi S, Itoyama Y, et al.
A randomized, controlled trial of fingolimod (FTY720) in Japanese patients with multiple sclerosis.
Mult Scler. 2012 Feb 21. [Epub ahead of print]
abstract

Epidemiology

El Adssi H, Debouverie M, Guillemin F.
Estimating the prevalence and incidence of multiple sclerosis in the Lorraine region, France, by the capture-recapture method.
Mult Scler. 2012 Feb 21. [Epub ahead of print]
abstract

Lalmohamed A, Bazelier MT, Van Staa TP, et al.
Causes of death in patients with multiple sclerosis and matched referent subjects: a population-based cohort study.
Eur J Neurol. 2012 Feb 21. doi: 10.1111/j.1468-1331.2012.03668.x. [Epub ahead of print]
abstract

Paediatric MS

Basiri K, Etemadifar M, Derakhshan F, et al.
Interferon-beta in pediatric multiple sclerosis patients: safety in short-term prescription.
Acta Med Iran. 2012 Feb;50(2):97-100.
abstract

Psychological aspects

Filippi M, Riccitelli G, Mattioli F, et al.
Multiple sclerosis: effects of cognitive rehabilitation on structural and functional MR imaging measures--an explorative study.
Radiology. 2012 Mar;262(3):932-40.
abstract

Physical activity

Kaipust JP, Huisinga JM, Filipi M, et al.
Gait variability measures reveal differences between multiple sclerosis patients and healthy controls.
Motor Control. 2012 Feb 16. [Epub ahead of print]
abstract

Korkmaz NC, Kirdi N, Temucin CM, et al.
Improvement of muscle strength and fatigue with high voltage pulsed galvanic stimulation in multiple sclerosis patients--a non-randomized controlled trial.
J Pak Med Assoc. 2011 Aug;61(8):736-43.
abstract

Scheidegger O, Kamm C, Humpert S, et al.
Corticospinal output during muscular fatigue differs in multiple sclerosis patients compared to healthy controls
Mult Scler. 2012 Feb 21. [Epub ahead of print]
abstract

D'Orio VL, Foley FW, Armentano F, et al.
Cognitive and motor functioning in patients with multiple sclerosis: neuropsychological predictors of walking speed and falls.
J Neurol Sci. 2012 Feb 20. [Epub ahead of print]
abstract

CCSVI

Mancini M, Morra VB, Di Donato O, et al.
Multiple sclerosis: cerebral circulation time.
Radiology. 2012 Mar;262(3):947-55.
abstract

Zaniewski M, Kostecki J, Kuczmik W, et al.
Neck duplex Doppler ultrasound evaluation for assessing chronic cerebrospinal venous insufficiency in multiple sclerosis patients.
Phlebology. 2012 Feb 22. [Epub ahead of print]
abstract

Simka M.
Possible pathomechanisms responsible for injury to the central nervous system in the settings of chronic cerebrospinal venous insufficiency.
Rev Recent Clin Trials. 2012 Feb 23. [Epub ahead of print]
abstract

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