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The MS Trust aims to keep you up-to-date with interesting and relevant research articles relating to multiple sclerosis. 

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MS research update – Abdominal massage for constipation – 4 December 2018

Summary

Around half of all people with MS experience bowel problems at some time. A common problem is constipation, defined as passing hard stools (poo or faeces) less than three times a week. There is a wide range treatment options including lifestyle changes to diet and exercise which can make a real difference. The aim of this study was to evaluate the effect of abdominal massage as a treatment for constipation.

191 participants who felt their constipation was “bothersome” were recruited at MS centres in the UK and assigned to one of two groups. One group was given advice on improving bowel care plus training in abdominal massage and encouraged to carry out massage for 10 minutes each day for six weeks. The other group was given advice only.

The study found that abdominal massage did improve bowel symptoms, but the effect was small and not statistically significant. The researchers concluded that, while the results do not justify routine use of abdominal massage for everyone reporting constipation, they do indicate that this approach would be worth considering as an additional option to help people manage constipation.


Background

Many people with MS experience bowel problems. A common problem is constipation, defined as passing hard stools (poo or faeces) less than three times a week. This can be accompanied by bloating of your abdomen and discomfort, tiredness and fatigue and loss of appetite. Constipation can cause other symptoms of MS, such as spasticity, to get worse or be more troublesome. It is well known that constipation can affect your self-esteem, energy levels, mood, relationships, sexual activities and your ability to work.

There are many approaches to managing constipation and straightforward lifestyle changes to diet and exercise can make a real difference. There are also a variety of treatment options including laxatives, suppositories and enemas. Massage therapy stimulates gut motility and has shown promise as a treatment for constipation in a small study of people with MS; the aim of this study was to test the effectiveness of abdominal massage in a larger group of people with MS.

How this study was carried out

191 participants who felt their constipation was “bothersome” were recruited at 12 MS centres around the UK. Participants were assigned to one of two groups:

  • advice to optimise bowel care
  • advice to optimise bowel care plus abdominal massage

Those in the abdominal massage group and/or their carer were taught how to do the abdominal massage and given a DVD and instruction book. A daily massage of 10 minutes duration was recommended. All participants had a weekly phone call from a health professional to check on progress and any changes or difficulties in their bowel management.

Participants completed questionnaires at the start of the study, at the end of 6 weeks of intervention and again at 24 weeks and kept a bowel diary for the duration of the study. To further assess the treatment, 20 participants had telephone interviews at the beginning and end of the trial.

What was found

At the end of the study, the abdominal massage group recorded a slight, but not statistically significant, improvement in the Neurogenic Bowel Dysfunction Score, a questionnaire which measures overall bowel symptoms. However, at the end of the study, participants in the abdominal massage group did record some important findings. They:

  • passed stools more frequently
  • felt that they emptied their bowel more completely
  • generally took fewer laxatives
  • felt better.

Interviews also identified that participants liked the fact that:

  • drugs were not involved
  • they could do the massage themselves
  • there was a lack of adverse side effects.

What does it mean?

The study found that abdominal massage lead to an improvement in bowel symptoms, but it was small and not statistically significant. The researchers conclude that while the results do not justify routine use of abdominal massage for everyone reporting constipation, they do indicate that this approach would be worth considering as an additional option to help people manage constipation.

McClurg D, et al.
Abdominal massage plus advice, compared with advice only, for neurogenic bowel dysfunction in MS: a RCT.
Health Technology Assessment 2018 Oct;22(58):1-134
Abstract
Full report

More about abdominal massage and managing constipation

If you would like to find out more about abdominal massage, you can read the instruction booklet and watch videos showing how to do it yourself or with the help of a carer on the study website.

Constipation is a common problem for people with MS. It’s not fully understood how and why constipation happens in MS but one of the causes may be that waste travels through the colon more slowly. As one of the functions of the colon is to reabsorb water, the longer it takes for waste to travel through the colon (known as transit time), the harder and smaller your stools become.

The good news is that there are lots of different ways to reduce constipation, though it may take some experimenting to find what works for you. Some self-management tips for improving constipation include:

  • eating regularly
  • getting enough fibre
  • drinking enough fluids
  • exercising regularly
  • posture when sitting on the toilet
  • giving it time
  • reviewing medicines
  • and of course, abdominal massage.

There is also a wide range of treatment options such as laxatives, stimulants and enemas. Health professionals, including your MS specialist nurse, GP and continence services can work with you to find the ones that are right for you.

Find out more about bowel problems and constipation on the MS Trust website. You can also download or order a free copy of our recently updated book Managing your bowels.

Research by topic areas...

Carers

Carling A, Nilsagård Y, Forsberg A.
Making it work: experience of living with a person who falls due to multiple sclerosis.
Disabil Rehabil. 2018 Oct 9:1-8. [Epub ahead of print]
abstract
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Causes of MS

Thomsen HL, Jessen EB, Passali M, et al.
The role of gluten in multiple sclerosis: A systematic review.
Mult Scler Relat Disord. 2018 Oct 23;27:156-163. [Epub ahead of print]
abstract

Alrouji M, Manouchehrinia A, Gran B, et al.
Effects of cigarette smoke on immunity, neuroinflammation and multiple sclerosis.
J Neuroimmunol. 2018 Oct 9. pii: S0165-5728(18)30130-9. [Epub ahead of print]
abstract

Rotstein DL, Cortese M, Fung TT, et al.
Diet quality and risk of multiple sclerosis in two cohorts of US women.
Mult Scler. 2018 Oct 23:1352458518807061. [Epub ahead of print]
abstract

Sestili C, Grazina I, La Torre G.
HBV vaccine and risk of developing multiple sclerosis: a systematic review and meta-analysis.
Hum Vaccin Immunother. 2018 Sep 27. [Epub ahead of print]
abstract

CCSVI

Traboulsee AL, Machan L, Girard JM, et al.
Safety and efficacy of venoplasty in MS: A randomized, double-blind, sham-controlled phase II trial.
Neurology. 2018 Oct 30;91(18):e1660-e1668.
abstract
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Co-existing conditions

Zulfiqar M, Qeadan F, Ikram A, et al.
Intracerebral hemorrhage in multiple sclerosis: a retrospective cohort study.
J Stroke Cerebrovasc Dis. 2018 Oct 29. pii: S1052-3057(18)30572-X. [Epub ahead of print]
abstract

Gutman JM, Kim K, Schwarzkopf R, et al.
Total hip and knee arthroplasty in patients with multiple sclerosis.
Int J MS Care. 2018 Sep-Oct;20(5):244-250.
abstract
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Diagnosis

Brownlee WJ.
Misdiagnosis of multiple sclerosis: If you have a hammer, everything looks like a nail?
Neurology. 2018 Oct 31. pii: 10.1212/WNL.0000000000006584. [Epub ahead of print]
abstract

Solomon AJ, Naismith RT, Cross AH.
Misdiagnosis of multiple sclerosis: Impact of the 2017 McDonald criteria on clinical practice.
Neurology. 2018 Oct 31. pii: 10.1212/WNL.0000000000006583. [Epub ahead of print]
abstract

Gebhardt M, Kropp P, Hoffmann F, et al.
Headache at the time of first symptom manifestation of multiple sclerosis: a prospective, longitudinal study.
Eur Neurol. 2018 Oct 26;80(3-4):115-120. [Epub ahead of print]
abstract

Lee DH, Peschke M, Utz KS, et al.
Diagnostic value of the 2017 McDonald criteria in patients with a first demyelinating event suggestive of relapsing remitting multiple sclerosis.
Eur J Neurol. 2018 Oct 26. [Epub ahead of print]
abstract

De Angelis F, Brownlee WJ, Chard DT, et al.
New MS diagnostic criteria in practice.
Pract Neurol. 2018 Sep 22. pii: practneurol-2018-001945. [Epub ahead of print]
abstract

Gaetani L, Prosperini L, Mancini A, et al.
2017 revisions of McDonald criteria shorten the time to diagnosis of multiple sclerosis in clinically isolated syndromes.
J Neurol. 2018 Nov;265(11):2684-2687.
abstract

Disease modifying drugs

Rejdak K, Stelmasiak Z, Grieb P.
Cladribine induces long lasting oligoclonal bands disappearance in relapsing multiple sclerosis patients: 10-year observational study.
Mult Scler Relat Disord. 2018 Oct 10;27:117-120. [Epub ahead of print]
abstract

Mazibrada G, Sharples C, Perfect I.
Real-world experience of fingolimod in patients with multiple sclerosis (MS Fine): An observational study in the UK.
Mult Scler J Exp Transl Clin. 2018 Oct 9;4(4):2055217318801638.
abstract
Read the full text of this paper

Saposnik G, Montalban X, Selchen D, et al.
Therapeutic inertia in multiple sclerosis care: a study of canadian neurologists.
Front Neurol. 2018 Sep 24;9:781.
abstract
Read the full text of this paper

Lim LL, Silva DG, Lo TC, et al.
Uveitis in patients with multiple sclerosis in clinical trials of fingolimod: incidence, prevalence and impact on disease course.
Ophthalmology. 2018 Oct 10. pii: S0161-6420(17)33667-9. [Epub ahead of print]
abstract

Tintore M, Vidal-Jordana A, Sastre-Garriga J.
Treatment of multiple sclerosis - success from bench to bedside.
Nat Rev Neurol. 2018 Oct 12. [Epub ahead of print]
abstract

Wray S, Havrdova E, Snydman DR, et al.
Infection risk with alemtuzumab decreases over time: pooled analysis of 6-year data from the CAMMS223, CARE-MS I, and CARE-MS II studies and the CAMMS03409 extension study.
Mult Scler. 2018 Oct 5:1352458518796675. [Epub ahead of print]
abstract
Read the full text of this paper

Melendez-Torres GJ, Armoiry X, Court R, et al.
Comparative effectiveness of beta-interferons and glatiramer acetate for relapsing-remitting multiple sclerosis: systematic review and network meta-analysis of trials including recommended dosages.
BMC Neurol. 2018 Oct 3;18(1):162.
abstract
Read the full text of this paper

Coyle PK, Khatri B, Edwards KR, et al.
Patient-reported outcomes in patients with relapsing forms of MS switching to teriflunomide from other disease-modifying therapies: Results from the global Phase 4 Teri-PRO study in routine clinical practice.
Mult Scler Relat Disord. 2018 Sep 15;26:211-218. [Epub ahead of print]
abstract
Read the full text of this paper

Houtchens MK, Edwards NC, Phillips AL.
Relapses and disease-modifying drug treatment in pregnancy and live birth in US women with MS.
Neurology. 2018 Oct 23;91(17):e1570-e1578.
abstract
Read the full text of this paper

Prosperini L, Annovazzi P, Boffa L, et al.
No evidence of disease activity (NEDA-3) and disability improvement after alemtuzumab treatment for multiple sclerosis: a 36-month real-world study.
J Neurol. 2018 Dec;265(12):2851-2860.
abstract

Palace J, Duddy M, Lawton M, et al.
Assessing the long-term effectiveness of interferon-beta and glatiramer acetate in multiple sclerosis: final 10-year results from the UK multiple sclerosis risk-sharing scheme.
J Neurol Neurosurg Psychiatry. 2018 Sep 21. pii: jnnp-2018-318360. [Epub ahead of print]
abstract
Read the full text of this paper

Burton JM, Traboulsee A.
Nothing ventured, nothing gained? navigating disease-modifying treatment in multiple sclerosis.
Can J Neurol Sci. 2018 Sep;45(5):487-488.
abstract

Min M, Spelman T, Lugaresi A, et al.
Silent lesions on MRI imaging - shifting goal posts for treatment decisions in multiple sclerosis.
Mult Scler. 2018 Oct;24(12):1569-1577.
abstract

Grand'Maison F, Yeung M, Morrow SA, et al.
Sequencing of high-efficacy disease-modifying therapies in multiple sclerosis: perspectives and approaches.
Neural Regen Res. 2018 Nov;13(11):1871-1874.
abstract
Read the full text of this paper

Antonazzo IC, Poluzzi E, Forcesi E, et al.
Liver injury with drugs used for multiple sclerosis: A contemporary analysis of the FDA Adverse Event Reporting System.
Mult Scler. 2018 Sep 19:1352458518799598. [Epub ahead of print]
abstract

Chitnis T, Arnold DL, Banwell B, et al.
Trial of fingolimod versus interferon beta-1a in pediatric multiple sclerosis.
N Engl J Med. 2018 Sep 13;379(11):1017-1027.
abstract

Xu X, Chi S, Wang Q, et al.
Efficacy and safety of monoclonal antibody therapies for relapsing remitting multiple sclerosis: A network meta-analysis.
Mult Scler Relat Disord. 2018 Oct;25:322-328.
abstract

Drugs in development

Bergman J, Burman J, Gilthorpe JD, et al.
Intrathecal treatment trial of rituximab in progressive MS: An open-label phase 1b study.
Neurology. 2018 Nov 13;91(20):e1893-e1901.
abstract

Kremer D, Akkermann R, Küry P, et al.
Current advancements in promoting remyelination in multiple sclerosis.
Mult Scler. 2018 Oct 1:1352458518800827. [Epub ahead of print]
abstract

Baldassari LE, Fox RJ.
Therapeutic advances and challenges in the treatment of progressive multiple sclerosis.
Drugs. 2018 Oct;78(15):1549-1566.
abstract

Fakih R, Matiello M, Chitnis T, et al.
Efficacy and safety of mycophenolate mofetil in progressive multiple sclerosis patients.
J Neurol. 2018 Nov;265(11):2688-2694.
abstract

Families

Andersen JB, Moberg JY, Niclasen J, et al.
Mental health among children of mothers with multiple sclerosis: A Danish cohort and register-based study.
Brain Behav. 2018 Oct;8(10):e01098.
abstract
Read the full text of this paper

Hacivelioğlu D, Tavşanli NG, Kosova F, et al.
Effect of multiple sclerosis on dyadic adjustment.
J Neurosci Nurs. 2018 Oct;50(5):303-307.
abstract

Other

Köpke S, Solari A, Rahn A, et al.
Information provision for people with multiple sclerosis.
Cochrane Database Syst Rev. 2018 Oct 14;10:CD008757.
abstract
Read the full text of this paper

Marrie RA, Leung S, Tyry T, et al.
Use of eHealth and mHealth technology by persons with multiple sclerosis.
Mult Scler Relat Disord. 2018 Oct 2;27:13-19. [Epub ahead of print]
abstract

Other treatments

Ladeira F, Mendonça M, Caetano A, et al.
Effect of patients' expectations on clinical response to fampridine treatment.
Neurol Sci. 2018 Oct 29. [Epub ahead of print]
abstract

Bakirtzis C, Konstantinopoulou E, Langdon DW, et al.
Long-term effects of prolonged-release fampridine in cognitive function, fatigue, mood and quality of life of MS patients: The IGNITE study.
J Neurol Sci. 2018 Dec 15;395:106-112.
abstract

Albrecht P, Bjørnå IK, Brassat D, et al.
Prolonged-release fampridine in multiple sclerosis: clinical data and real-world experience. Report of an expert meeting.
Ther Adv Neurol Disord. 2018 Oct 5;11:1756286418803248.
abstract
Read the full text of this paper

Renfrew ML, Flowers P, Lord AC, et al.
An exploration of the experiences and utility of functional electrical stimulation for foot drop in people with multiple sclerosis.
Disabil Rehabil. 2018 Oct 9:1-9. [Epub ahead of print]
abstract

Edwards T, Motl RW, Sebastião E, et al.
Pilot randomized controlled trial of functional electrical stimulation cycling exercise in people with multiple sclerosis with mobility disability.
Mult Scler Relat Disord. 2018 Sep 8;26:103-111. [Epub ahead of print]
abstract

Arroyo González R.
A review of the effects of baclofen and of THC:CBD oromucosal spray on spasticity-related walking impairment in multiple sclerosis.
Expert Rev Neurother. 2018 Oct;18(10):785-791.
abstract

Paediatric MS

Young B, Waubant E, Lulu S, et al.
Puberty onset and pediatric multiple sclerosis activity in boys.
Mult Scler Relat Disord. 2018 Oct 22;27:184-187. [Epub ahead of print]
abstract

Pétrin J, Fiander M, Doss PMIA, et al.
A scoping review of modifiable risk factors in pediatric onset multiple sclerosis: building for the future.
Children (Basel). 2018 Oct 26;5(11). pii: E146.
abstract
Read the full text of this paper

Nourbakhsh B, Bhargava P, Tremlett H, et al.
Altered tryptophan metabolism is associated with pediatric multiple sclerosis risk and course.
Ann Clin Transl Neurol. 2018 Sep 27;5(10):1211-1221.
abstract
Read the full text of this paper

Lavery AM, Waubant E, Casper TC, et al.
Urban air quality and associations with pediatric multiple sclerosis.
Ann Clin Transl Neurol. 2018 Sep 27;5(10):1146-1153.
abstract
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Otallah S, Banwell B.
Pediatric multiple sclerosis: an update.
Curr Neurol Neurosci Rep. 2018 Sep 18;18(11):76.
abstract

Pregnancy and childbirth

Houtchens MK, Edwards NC, Schneider G, et al.
Pregnancy rates and outcomes in women with and without MS in the United States.
Neurology. 2018 Oct 23;91(17):e1559-e1569.
abstract
Read the full text of this paper

Prognosis

Heesen C, Scalfari A, Galea I.
Prognostic information for people with MS: Impossible or inevitable?
Mult Scler. 2018 Oct 16:1352458518807101. [Epub ahead of print]
abstract

Razzolini L, Portaccio E, Stromillo ML, et al.
The dilemma of benign multiple sclerosis: Can we predict the risk of losing the "benign status"? A 12-year follow-up study.
Mult Scler Relat Disord. 2018 Aug 18;26:71-73. [Epub ahead of print]
abstract

Provision of care

Hobart J, Bowen A, Pepper G, et al.
International consensus on quality standards for brain health-focused care in multiple sclerosis.
Mult Scler. 2018 Nov 1:1352458518809326. [Epub ahead of print]
abstract
Read the full text of this paper

Soelberg Sorensen P, Giovannoni G, Montalban X, et al.
The multiple sclerosis care unit.
Mult Scler. 2018 Oct 23:1352458518807082. [Epub ahead of print]
abstract
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Psychological aspects

Eijkholt M, Sparling A.
Health, honesty and happiness: Authenticity and anonymity in social media participation of individuals with multiple sclerosis.
Mult Scler Relat Disord. 2018 Sep 19;27:121-126. [Epub ahead of print]
abstract

Henry A, Tourbah A, Camus G, et al.
Anxiety and depression in patients with multiple sclerosis: The mediating effects of perceived social support.
Mult Scler Relat Disord. 2018 Oct 2;27:46-51. [Epub ahead of print]
abstract

Rehabilitation

Street T, Singleton C.
Five-year follow-up of a longitudinal cohort study of the effectiveness of functional electrical stimulation for people with multiple sclerosis.
Int J MS Care. 2018 Sep-Oct;20(5):224-230.
abstract
Read the full text of this paper

Leone C, Kalron A, Smedal T, et al.
Effects of rehabilitation on gait pattern at usual and fast speeds depend on walking impairment level in multiple sclerosis.
Int J MS Care. 2018 Sep-Oct;20(5):199-209.
abstract
Read the full text of this paper

Knox KB, Clay L, Stuart-Kobitz K, et al.
Perspectives on walking from people with multiple sclerosis and reactions to video self-observation.
Disabil Rehabil. 2018 Oct 22:1-8. [Epub ahead of print]
abstract

Scheidler AM, Kinnett-Hopkins D, Learmonth YC, et al.
Targeted ballet program mitigates ataxia and improves balance in females with mild-to-moderate multiple sclerosis.
PLoS One. 2018 Oct 18;13(10):e0205382.
abstract
Read the full text of this paper

Coulter EH, Bond S, Dalgas U, et al.
The effectiveness of interventions targeting physical activity and/or sedentary behaviour in people with Multiple Sclerosis: a systematic review.
Disabil Rehabil. 2018 Oct 5:1-19. [Epub ahead of print]
abstract

Barbarulo AM, Lus G, Signoriello E, et al.
Integrated cognitive and neuromotor rehabilitation in multiple sclerosis: a pragmatic study.
Front Behav Neurosci. 2018 Sep 5;12:196.
abstract
Read the full text of this paper

Sebastião E, McAuley E, Shigematsu R, et al.
Home-based, square-stepping exercise program among older adults with multiple sclerosis: results of a feasibility randomized controlled study.
Contemp Clin Trials. 2018 Oct;73:136-144.
abstract

Tedesco Triccas L, McLening B, Hendrie W, et al.
Is there a standard procedure for assessing and providing assistive devices for people with neuro-disabling conditions in United Kingdom? A nation-wide survey.
Disabil Health J. 2018 Aug 11. pii: S1936-6574(18)30146-8. [Epub ahead of print]
abstract

Demaneuf T, Aitken Z, Karahalios A, et al.
Effectiveness of exercise interventions for pain reduction in people with multiple sclerosis: a systematic review and meta-analysis of randomized controlled trials.
Arch Phys Med Rehabil. 2018 Sep 19. pii: S0003-9993(18)31191-2. [Epub ahead of print]
abstract

Ewanchuk BW, Gharagozloo M, Peelen E, et al.
Exploring the role of physical activity and exercise for managing vascular comorbidities in people with multiple sclerosis: A scoping review.
Mult Scler Relat Disord. 2018 Aug 24;26:19-32. [Epub ahead of print]
abstract

Hanson M, Concialdi M.
Motor imagery in multiple sclerosis: exploring applications in therapeutic treatment.
J Neurophysiol. 2018 Sep 12. [Epub ahead of print]
abstract

Rilo O, Peña J, Ojeda N, et al.
Integrative group-based cognitive rehabilitation efficacy in multiple sclerosis: a randomized clinical trial.
Disabil Rehabil. 2018 Jan;40(2):208-216.
abstract
Read the full text of this paper

Cattaneo D, Rasova K, Gervasoni E, et al.
Falls prevention and balance rehabilitation in multiple sclerosis: a bi-centre randomised controlled trial.
Disabil Rehabil. 2018 Mar;40(5):522-526.
abstract

Relapses

Matza LS, Kim K, Phillips G, et al.
Multiple sclerosis relapse: Qualitative findings from clinician and patient interviews.
Mult Scler Relat Disord. 2018 Sep 26;27:139-146. [Epub ahead of print]
abstract

Achiron A, Sarova-Pinhas I, Magalashvili D, et al.
Residual disability after severe relapse in people with multiple sclerosis treated with disease-modifying therapy.
Mult Scler. 2018 Nov 1:1352458518809903. [Epub ahead of print]
abstract

Nazareth TA, Rava AR, Polyakov JL, et al.
Relapse prevalence, symptoms, and health care engagement: patient insights from the Multiple Sclerosis in America 2017 survey.
Mult Scler Relat Disord. 2018 Sep 7;26:219-234. [Epub ahead of print]
abstract
Read the full text of this paper

Hervás-García JV, Ramió-Torrentà L, Brieva-Ruiz L, et al.
Comparison of two high doses of oral methylprednisolone for multiple sclerosis relapses: a pilot, multicentre, randomized, double-blind, non-inferiority trial.
Eur J Neurol. 2018 Oct 23. [Epub ahead of print]
abstract

Conway BL, Zeydan B, Uygunoğlu U, et al.
Age is a critical determinant in recovery from multiple sclerosis relapses.
Mult Scler. 2018 Oct 10:1352458518800815. [Epub ahead of print]
abstract

Review

Dobson R, Giovannoni G.
Multiple sclerosis - a review.
Eur J Neurol. 2018 Oct 9. [Epub ahead of print]
abstract

Oh J, Vidal-Jordana A, Montalban X.
Multiple sclerosis: clinical aspects.
Curr Opin Neurol. 2018 Dec;31(6):752-759.
abstract

Stem cells

Bose G, Atkins HL, Bowman M, et al.
Autologous hematopoietic stem cell transplantation improves fatigue in multiple sclerosis.
Mult Scler. 2018 Sep 25:1352458518802544. [Epub ahead of print]
abstract

Symptoms and symptom management

Marrie RA, Patel R, Figley CR, et al.
Diabetes and anxiety adversely affect cognition in multiple sclerosis.
Mult Scler Relat Disord. 2018 Oct 23;27:164-170. [Epub ahead of print]
abstract
Read the full text of this paper

Christogianni A, Bibb R, Davis SL, et al.
Temperature sensitivity in multiple sclerosis: An overview of its impact on sensory and cognitive symptoms.
Temperature (Austin). 2018 Sep 5;5(3):208-223.
abstract

McCreary JK, Rogers JA, Forwell SJ.
Upper limb intention tremor in multiple sclerosis: an evidence-based review of assessment and treatment.
Int J MS Care. 2018 Sep-Oct;20(5):211-223.
abstract
Read the full text of this paper

Beckmann Y, Türe S.
Headache characteristics in multiple sclerosis.
Mult Scler Relat Disord. 2018 Sep 22;27:112-116. [Epub ahead of print]
abstract

Sammaraiee Y, Yardley M, Keenan L, et al.
Intrathecal baclofen for multiple sclerosis related spasticity: A twenty year experience.
Mult Scler Relat Disord. 2018 Oct 15;27:95-100. [Epub ahead of print]
abstract

Sormani MP, De Stefano N, Giovannoni G, et al.
Learning ability correlates with brain atrophy and disability progression in RRMS.
J Neurol Neurosurg Psychiatry. 2018 Oct 15. pii: jnnp-2018-319129. [Epub ahead of print]
abstract
Read the full text of this paper

Tudor KI, Eames S, Haslam C, et al.
Identifying barriers to help-seeking for sexual dysfunction in multiple sclerosis.
J Neurol. 2018 Dec;265(12):2789-2802.
abstract

Cortese A, Conte A, Ferrazzano G, et al.
Photophobia in multiple sclerosis.
Mult Scler Relat Disord. 2018 Sep 8;26:55-57. [Epub ahead of print]
abstract

Carta MG, Paribello P, Anastasia A, et al.
Pharmacological management of depression in patients with multiple sclerosis.
Expert Opin Pharmacother. 2018 Oct;19(14):1533-1540.
abstract

Vitamin D

Holmøy T, Røsjø E, Zetterberg H, et al.
Vitamin D supplementation and neurofilament light chain in multiple sclerosis.
Acta Neurol Scand. 2018 Oct 13. [Epub ahead of print]
abstract

McLaughlin L, Clarke L, Khalilidehkordi E, et al.
Vitamin D for the treatment of multiple sclerosis: a meta-analysis.
J Neurol. 2018 Dec;265(12):2893-2905.
abstract

Jagannath VA, Filippini G, Di Pietrantonj C, et al.
Vitamin D for the management of multiple sclerosis.
Cochrane Database Syst Rev. 2018 Sep 24;9:CD008422.
abstract
Read the full text of this paper

Work

Clemens L, Langdon D.
How does cognition relate to employment in multiple sclerosis? A systematic review.
Mult Scler Relat Disord. 2018 Sep 15;26:183-191. [Epub ahead of print]
abstract

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