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A to Z of MS Dantrolene sodium

Product name

Dantrium

Dantrolene sodium is a drug used to treat chronic, severe spasticity. The NICE Guideline states that it should only be used if treatment when baclofen or gabapentin has not been successful.

How dantrolene works

Dantrolene is thought to work by stopping some electrical impulses travelling within the muscles. This contrasts with most other spasticity drugs that work to prevent or inhibit the way the brain and spinal cord communicate with the rest of the body.

How dantrolene is given

Dantrolene sodium is taken orally as tablets. Dosage varies but should not exceed 400mg per day.

Side effects and contra indications

Side effects include drowsiness, dizziness, weakness and fatigue. All of these may be transient. Another side effect can be diarrhoea, which can be severe. Dantrolene should not be taken by people with a history of liver dysfunction, or by pregnant or breastfeeding women.

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