A to Z of MS Desmopressin
Product names
Desmotabs
Desmopressin is a drug used in the treatment of continence problems in MS. It is specifically used with people who experience nocturia – the need to go to the toilet frequently during the night. The drug can also be used during the day if regular access to a toilet is not convenient, for instance during long haul travelling. However, it is essential that the user recognises the possible dangers of retaining too much water if it is used more than once in 24 hours.
How desmopressin works
Desmopressin is synthetic antidiuretic hormone, which means that it suppresses the production of urine by the kidneys. It can reduce urine production for six to eight hours.
How is desmopressin given?
Desmopressin is usually taken orally as a tablet.
A nasal spray (product name Desmospray) is now used less frequently due to concerns about the effect on an individual's sodium levels.
Side effects and contraindications
Rarely desmopressin tablets can cause a lowering of sodium levels in the blood (hyponatremia). The symptoms of this are nausea, headache and generally feeling unwell. People with dependent oedema (an increase in fluid in the body, which can be caused by inactivity or reduced mobility) should not use desmopressin.
Reference
Eckford S, et al.
Desmopressin in the treatment of nocturia and enuresis in patients with multiple sclerosis.
British Journal of Urology 1994;74:733-735.