A to Z of MS Diazepam

Product name

Valium

Diazepam has been used in the treatment of spasticity and spasms since the 1960s. The side effects of diazepam and the potential for users to become dependent on the drug, mean that it tends to be used only when other spasticity treatments are not proving effective. Research that compared diazepam with baclofen, the current standard treatment, found that both drugs had a similar effect on the reduction of spasticity.

How diazepam works

Diazepam is one of a class of drugs called central nervous system (CNS) depressants, which slow down the nervous system. It is also an anticonvulsant and muscle relaxant.

How diazepam is given

Diazepam is taken orally as tablets. Treatment starts with a low dose that is built up slowly over weeks until the drug is proving effective or until the side effects prevent a higher dose. Treatment should not be stopped suddenly as this can cause withdrawal symptoms.

Side effects and contraindications

Side effects include drowsiness, fatigue, unsteadiness and feeling less alert. Pregnant and breastfeeding women should not take diazepam. Diazepam should not be taken with alcohol. It can also interact with antihistamines, sedatives, tranquillisers, prescription pain medications and sleeping medications.

Reference

Roussan M, et al.
Baclofen versus diazepam for the treatment of spasticity and long-term follow-up of baclofen therapy.
Pharmatherapeutica 1985;4(5):278-284.
abstract

Return to index