A to Z of MS Lamotrigine
Product name
Lamictal
Lamotrigine is an anti-epilepsy drug that has been used experimentally in MS to reduce pain associated with trigeminal neuralgia and spasms. Lamotrigine is not currently recommended in the NICE Guidelines for the treatment of pain in MS.
Because of its effect on regulating the chemical processes within nerves, lamotrigine is also being studied to see if it can help stop further damage to nerve cells (an approach known as neuroprotection).
How lamotrigine works
Lamotrigine is an anticonvulsant drug that reduces or blocks some messages from the brain to the rest of the body.
How lamotrigine is given
Lamotrigine is given orally as tablets. Experimental doses range from 25-400mg per day. People start on a low dose that is gradually increased.
Side effects and contraindications
Side effects include rash, headache, stomach upsets, double vision, dizziness and ataxia (problems with coordination). Lamotrigine can stop some types of oral contraceptive pill from working, so this should be taken into account.