A to Z of MS Methotrexate
Product names
Maxtrex
Methotrexate is an immunosuppressant drug used in the treatment of rheumatoid arthritis and psoriasis. Studies have looked at low dose methotrexate as a treatment for progressive MS and found that it may have a role in slowing progression and helping with psychological symptoms in people with moderate disability.
How is methotrexate given?
Methotrexate is taken orally as tablets.
Side effects and contraindications
Methotrexate was well tolerated at the low doses used in research. Longer term use may be associated with serious side effects including lung and liver problems and the suppression of bone marrow.
Reference
Goodkin DE, et al.
Low dose (7.5mg) oral methotrexate reduces the rate of progression in chronic progressive multiple sclerosis.
Annals of Neurology 1995;37:30-40.