A to Z of MS Modafinil
Product name
Provigil
Modafinil promotes wakefulness and has been used in treating people experiencing excessive sleepiness due to narcolepsy, shift work sleep disorder and other forms of sleep disruption. Research shows that it is an effective treatment for the management of MS fatigue in some people.
How modafinil works
It is thought that modafinil works by selective activation of a particular part of the brain called the hypothalamus. This area is thought to control normal sleep and wakefulness patterns. Unlike central nervous system stimulants, modafinil does not result in any rebound hypersomnia (or 'crash') as it wears off.
How is modafinil given?
Modafinil is taken orally as tablets.
Side effects and contraindications
Modafinil is generally well tolerated with mild side effects, which can include headache, nausea and asthenia (weakness, loss of strength). Modafinil reduces the effect of contraceptive drugs.
Reference
Rammohan KW, et al.
Efficacy and safety of modafinil (Provigil) for the treatment of fatigue in multiple sclerosis: a two centre phase 2 study.
Journal of Neurology, Neurosurgery and Psychiatry 2002;72(2):179-183.