A to Z of MS Phenol

Phenol is a neurolytic agent, which means that it impairs the conduction of nerves. In multiple sclerosis it has been used in the treatment of severe spasticity where other treatment options have proven ineffective.

How phenol works

Phenol destroys the nerve conduction that is causing spasticity. As the effect is permanent, it is used with people who experience spasticity but who have no feeling and control in their legs and no control of bowel or bladder function.

How is phenol given?

Phenol is injected directly into the space within the spinal column, called the intrathecal space.

Reference

Jarrett L, et al.
Managing severe lower limb spasticity in multiple sclerosis: does intrathecal phenol have a role?
Journal of Neurology Neurosurgery and Psychiatry 2002;73(6):705-709.
abstract

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