A to Z of MS
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A to Z of MS Tadalafil (Cialis)
Tadalafil is a prescription medicine for the treatment of erectile dysfunction in men.
How tadalafil works
Erectile dysfuntion is the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. In multiple sclerosis this is commonly associated with bladder symptoms and both disorders are believed to be as a direct result of damage to the nerves in the spinal cord.
Tadalafil works by delaying the action of enzymes called PDE5 (phosphodiesterase type 5), which regulate blood flow in the penis. Altering levels of this enzyme means that normal sexual stimulation leads to better erections.
How is tadalafil taken
Tadalafil is taken at least half an hour before sexual activity, though is most effective about two hours after it is taken. People who anticipate needing treatment more than once a week can be prescribed a smaller daily dose. This continuous dose must be regularly reviewed.
Some people may still experience effects up to 36 hours after use
Side effects and contraindications
Common side effects include headaches, flushing, upset stomach, visual disorders, nasal congestion and dizziness. Tadalafil should not be taken by people receiving treatment with drugs containing nitrates, such as are used to treat angina. Tadalafil must be used with caution by people with existing heart conditions or problems with liver or kidney function or low blood pressure.
Lombardi G, et al.
Efficacy and safety of tadalafil for erectile dysfunction in patients with multiple sclerosis.
Journal of Sexual Medicine 2010;7(6):2192-2200
Lombardi G, et al.
Treating erectile dysfunction and central neurological diseases with oral phosphodiesterase type 5 inhibitors. Review of the literature.
Journal of Sexual Medicine 2012;9(4):970-985
Patient Information Leaflets
- Cialis (EMC website)