A to Z of MS Tadalafil
Product name
Cialis
Tadalafil is a prescription medicine for the treatment of erectile dysfunction in men.
How tadalafil works
Erectile dysfuntion is the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. In multiple sclerosis this is commonly associated with bladder problems and both disorders are believed to be as a direct result of damage to the nerves in the spinal cord.
Whilst psychologically driven erections are likely to have been impaired by MS, reflex responses remain intact. Tadalafil works by delaying the action of enzymes called phosphodiesterases. This results in relaxing the blood vessels and allowing blood to flow into the penis on sexual stimulation.
How tadalafil is given
Tadalafil is taken orally at least 30 minutes before sexual activity is planned. The effect may persist for up to 36 hours. Dose ranges from 5-20mg as necessary. Maximum dose frequency is once a day, but daily use of tadalafil is not recommended.
Side effects and contraindications
Prior to starting treatment the cardiovascular status of the individual should be assessed, as there is a degree of cardiac risk associated with sexual activity. Tadalafil can cause the blood pressure to drop suddenly if taken with certain other medications. A sudden drop in blood pressure can cause dizziness or fainting.
The most common side effects include headache, indigestion, back pain, muscle aches, flushing, or rhinitis (stuffy or runny nose). The only absolute contraindication to tadalafil is concurrent nitrate therapy.