Other names: Lioresal, Lyflex
Baclofen is a drug that has a long history of use as a treatment for spasticity and spasms in multiple sclerosis. The NICE guideline for MS suggests that baclofen should be the first drug used when treating MS spasticity.
How do I take baclofen?
Baclofen is taken by mouth (orally) as tablets or as a liquid. Treatment usually starts with a small dose that can be increased in steps until it is most effective or side effects become a problem.
If you have more advanced spasticity, a smaller dose of the drug can be given directly into the spine (intrathecally) using an implanted pump.
What side effects could I get with baclofen?
Stopping treatment suddenly may cause severe withdrawal symptoms. These can include hallucinations and seizures. You should talk to your doctor before stopping treatment, and plan a gradual reduction of the daily dose.
How does baclofen work?
Baclofen is a type of drug known as a gamma aminobutyric acid (GABA)-B receptor agonist. This means that it reduces the transmission of messages between nerve cells. This means that muscles are less likely to contract and become stiff.
Last reviewed: 23 March 2016
This page will be reviewed within three years