Other names: Aricept
Donepezil is a drug used in the treatment of Alzheimer's disease. It has been studied as a treatment for impaired memory in people with cognitive symptoms due to multiple sclerosis.
A small study followed 69 people with MS taking either donepezil or a placebo for 24 weeks. It found that twice as many people in the treatment group reported memory improvement (65.7%) than those on placebo (32.4%). Health professionals also reported that more people in the treatment group showed improved cognitive symptoms. However, a larger study involving 120 people with MS showed no difference in improving memory between donepezil and placebo.
How is donepezil given?
Donepezil is taken orally as tablets.
Side effects and contraindications
Donepezil is generally well tolerated with no serious side effects observed during the studies other than reports of unusual dreams.
Last updated: November 2017
Last reviewed: January 2014
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