You self-inject Brabio under the skin either daily or three times a week to reduce the number and severity of relapses. It reduces the number of relapses by about one third (30%), compared to taking placebo.
Common side effects include injection site reaction.
What is Brabio used for in MS?
Brabio is a moderately effective (category 1.1) DMD; in clinical trials people taking Brabio had about 30% fewer relapses than people taking placebo. In clinical trials, MRI scans showed people taking Brabio had fewer, smaller or no new areas of active MS (lesions).
Who can take Brabio?
Brabio can be prescribed for adults with active relapsing remitting MS.
Brabio taken daily has been available for use on the NHS since 2018. Brabio three times a week has been approved since 2015. It can only be prescribed by a neurologist.
Conception and pregnancy
Pregnancy is not recommended during treatment.
If you are trying for a family, talk to your MS nurse or neurologist about whether you should continue to take Brabio until you are pregnant.
If you become pregnant while on Brabio, your neurologist or MS nurse may recommend you stop taking it.
How do I take Brabio?
You self-inject Brabio under the skin. Two doses are available: one for daily injections and another for three times a week injections. Brabio is supplied in single-use, pre-filled syringes. An automatic injection device is also available to make injections easier.
Your MS nurse will show you how to do the injections, discuss the practicalities and offer advice or training and ongoing support if you should need it.
What side effects could I get with Brabio?
Common side effects include injection site reactions such as lipoatrophy (leading to permanent indentations in the skin), redness, swelling, itching or some pain at the site.
Occasionally, some people may experience a reaction, known as the immediate post-injection reaction (IPIR), shortly after injection. This may cause flushing, chest tightness, shortness of breath and palpitations. This reaction can last 15-30 minutes, will ease without any treatment and doesn't cause long-term problems. If symptoms last longer than 30 minutes, contact your doctor immediately or go straight to the A&E department of your nearest hospital.
Common side effects (affecting more than 1 person in 100)
- injection site reactions
- lipoatrophy (indentations in the skin)
- depression, anxiety
- feeling weak
- chest pain, pain
- swollen lymph nodes
- gastrointestinal changes
Less common side effects (affecting less than 1 person in 100)
- blood cell changes
- extra heartbeats
- thyroid changes
- dilation of blood vessels
- immediate post-injection reaction (IPIR)
A full list of side effects is included in the manufacturer's Patient Information Leaflet.
Assessment before treatment
Blood tests are not generally required before starting treatment with Brabio.
Assessment during treatment
There is no need for routine blood tests during treatment, but your MS nurse will arrange regular appointments to review how you are coping with Brabio.
In the GATE study the glatiramer acetate generic drug Brabio was compared to the branded version Copaxone for treatment of relapsing remitting MS:
- Equivalence of Generic Glatiramer Acetate in Multiple Sclerosis: A Randomized Clinical Trial.
In this clinical trial, 794 people with relapsing remitting MS took either Brabio or Copaxone for nine months. The main measures of the study was the number of gadolinium-enhancing lesions, annualised relapse rates and EDSS score, as well as assessing safety and tolerability. As a treatment for relapsing remitting MS compared to Copaxone, Brabio had an equivalent efficacy, safety and tolerability.
Compare Disease Modifying Drugs
Use our MS Decisions aid to help filter and compare the different types of disease modifying drugs (DMDs) that are available to treat relapsing MS.
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