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Depression is common in the general population, but research suggests that people living with long term conditions such as MS have a higher risk of experiencing depression. It can be a symptom of MS or develop as a consequence of living with the condition. Depression is different from low mood, it is persistent and can affect all aspects of your life, it is often related to anxiety and stress. Depression can be lonely and isolating, but it is a recognised and treatable condition.

Many of the symptoms associated with depression such as fatigue, constipation and sleep problems are also symptoms of MS, which can make recognising depression even more difficult. However, two simple questions have been devised to establish if you or someone you know is depressed:

  • During the last month have you often been bothered by feeling down, depressed or hopeless?
  • During the last month have you often been bothered by having little or no pleasure in doing things?

If the answer is "yes" to either of these questions, it is important that you speak to your GP or MS specialist team as it is not usual to feel low all the time. 

Fast facts

  • Depression is not a sign of weakness, or because of something you've done.
  • Help is available from your GP, MS specialist nurse or specialist MS clinic.
  • Depression is treatable and can be managed successfully, your GP or MS team will work with you to find the approach that’s right for you.

What is depression?

Everyone feels sad or down at times but clinical depression is different. It is constantly present and interferes with your everyday activities. Depression can be mild, moderate or severe and you can experience different levels of depression at different times. If you are depressed you often lose pleasure in things that were once enjoyable, you may give up usual activities such as hobbies and lose interest in seeing friends and family. Some people even feel that life is no longer worth living and have thoughts of suicide.

Mild depression is when a person has a small number of symptoms that have a limited effect on their daily life.

Moderate depression is when a person has more symptoms that can make their daily life much more difficult than usual.

Severe depression is when a person has many symptoms that can make their daily life extremely difficult.

What causes depression?

The causes of depression in the general population are not fully understood, but it is thought that an imbalance in brain chemistry causes a drop in mood. Anyone can develop depression at any time in their life without any apparent cause or reason. It is not due to an inability to cope with life, or a weakness or failure of any sort. Depression can be triggered by stressful events in your life such as bereavement and it is also thought there may be some genetic factors, so if a close member of your family experiences depression it is more likely that you will too. If you have MS there are also additional factors. Below are some of the experiences that can lead to depression.

Life events

You might be more at risk of developing depression if:

  • you have experienced a stressful life event such as a relationship break-down or a bereavement
  • you have a family history of depression
  • you are a woman who has recently given birth
  • you are socially isolated
  • you have drug or alcohol problems.

All these life events are just as likely whether you have MS or not.

Living with MS

The challenges of living with multiple sclerosis can also lead to depression. Living with uncertainty, feeling helpless, experiencing loss of opportunity and the social isolation that disability may bring can all be factors for developing depression. Increased levels of stress and experiencing symptoms such as chronic pain and overwhelming fatigue can also be contributing factors. However, research has shown MS depression isn’t clearly related to disability or having lived with the condition for a long time, and in fact may be more common earlier in the disease, especially if it is severe. The amount of social support that you have can also make a difference, for people who are socially isolated depression can be more severe.  What does seem an important factor is how you adjust to living with MS and the kinds of strategies that you use to manage your condition.

Site of MS lesions

Studies have shown that depression can also occur as a result of MS itself, because if MS lesions happen to occur in areas of the brain that are associated with mood they can lead to depression.

Side effects of drugs used to treat other MS symptoms

Some drugs prescribed to treat MS can also contribute to depression. These include steroids used to treat MS relapses, muscle relaxants used to treat spasticity and spasms and some disease modifying drugs.

How many people get depression?

It is estimated that around half of all people with multiple sclerosis will experience an episode of depression at some time, this is three times higher than for the general population. The risk of suicide for people with MS is also significantly higher, young men within the first five years of MS diagnosis have been found to be most at risk of ending their own lives.

What can I do if I think I’m depressed?

It is important to let someone know how you feel. Clinical depression can be difficult to identify and you may not always be able to recognise depression yourself. It can be hard to talk about how you are feeling and the stigma that is sometimes associated with mental health problems can also act as a barrier to discussions. Family and friends can play a key role in helping you to identify or recognise depression.

Depression is often diagnosed by a GP, but your MS specialist nurse or neurologist may also recognise the signs of depression. There is no simple test such as a blood test to find out if you are depressed. Your health professionals rely on descriptions of the symptoms you are experiencing and the effect it is having on your life. They will then work with you to find the best approach to treatment.

The symptoms of depression are many and varied. Recognising depression when you have MS can be difficult as you may already experience some of the symptoms usually associated with depression such as fatiguepoor concentration and sleep problems. The important thing to focus on are changes including:

  • low mood all the time for at least two weeks
  • negative thoughts about yourself and the future which might not be related to the level of disability that you experience
  • not being able to take pleasure in routine things that you have previously enjoyed such as eating, watching TV or talking to friends
  • thoughts of suicide.

It has also been suggested that in MS, depression causes increased problems with thinking, feeling irritable, frustrated and discouraged. Worsening of MS symptoms that you already have in the absence of infection or relapse and deepening of fatigue could also be flags for concern.

Simply describing the symptoms of depression cannot capture the enormous impact it can have - it can affect personal, social and professional aspects of your life. Without the right help depression can spiral out of control, so it is important to speak to a GP or another person you trust as early as possible. Depression may make you want to withdraw from intimate or social relationships, family and friends may not recognise that this is due to the condition and may misunderstand this as rejection or disinterest, which in turn can lead to a lack of empathy or sensitivity towards you - this can feed in to the depression and lead to further social withdrawal.

Depression can interfere with your ability to concentrate and so can affect work performance. This may be perceived as laziness or incompetence by your work colleagues if they are unaware of the situation.

Depression is often accompanied by feelings of despair, uselessness or lack of self-worth. This can lead to self-neglect, you may stop caring for yourself in the way that you usually would and may stop following a healthy lifestyle or neglect to take your usual prescribed medication - this may be your MS medication and/or any medication prescribed to treat your depression. Because of the impact depression can have on you and the management of your MS, it is important to seek help.    

If life seems unbearable

Studies have found that over a quarter of people with MS think about suicide. This can happen when the future looks bleak and you may think friends and family would be better off if you weren’t around. Whilst many people think about suicide, few go on to carry this out. If you are having thoughts of suicide or you find yourself severely down, the Samaritans provide a free 24 hour telephone line in the UK and Republic of Ireland on 116 123 and can help you through until you can contact your regular team of health professionals. Friends and family can also help - the vital thing is to involve other people even though this may not be easy.

How is depression treated?

There are a number of approaches to treating depression and the best solution for you will depend on the severity of your depression as well as other factors such as your personal preferences, sources of support and any past history of depression. Treatments are often used in combination. Your GP, MS specialist nurse or neurologist will work with you to decide the best course of action. You may be referred to a neuropsychologist where this service is available, or to other members of the mental health team.          

NICE has offered useful guidance on what should happen when you talk to a health professional for the first time about depression.  

Self-management – what can I do?

In mild to moderate depression, self-management is the approach recommended by the NICE guidelines. This may include advice on increasing your levels of physical activity for example through appropriate exercise, adopting healthier lifestyle habits such as giving up smoking, minimising stress, improving your sleep and relaxation or mindfulness techniques. You may also want to consider accessing support through a self-help group, telephone counselling service, online discussion forum or one of the many mental health charities. Your health professional team will regularly review your progress to ensure that your mood is improving. 

Think about signs to look out for if you start to get low again. Mine were things like not contacting friends, not bothering with my appearance and shutting myself away

Recognising your own risk factors can also be really important so keeping a diary of how you feel can be valuable.

St John's wort is an unlicensed herbal remedy that is used by some people to treat their depression. However, concerns about the correct dose, variations between preparations from different manufacturers and the potential for serious drug interactions (including with warfarin and oral contraceptives) mean it is not currently recommended by NICE for the treatment of depression.

Talking therapies

Talking therapies or psychological approaches aim to help you identify and overcome negative thought patterns associated with depression. They are usually recommended for mild to moderate cases of depression. Unfortunately access to talking therapies can be fairly limited on the NHS.

Cognitive behavioural therapy (CBT) is based on the idea that the way you think about a situation affects how you act. In turn, actions can affect how you think and feel. Therefore both the act of thinking (cognition) and behaviour need to change at the same time. Cognitive behavioural therapy has been shown to be effective in treating less severe cases of depression in MS. It can take some time for referral to a psychologist but online courses can help.

Counselling is a form of therapy that helps you to think about the problems you are experiencing in your life and to identify ways of overcoming or managing them. Counselling is different from other psychological approaches as the therapist has a more passive role and provides more of a listening approach. 

Other talking therapies include psychotherapy, family therapy, couples therapy and group therapy. They may be available from your local MS Therapy centre

Read more about talking therapies


In moderate to severe cases of depression, or where previous treatment approaches have not been effective, you may be offered antidepressants. Initially you will usually be prescribed the lowest possible dose of a drug. The effects of antidepressants may not be immediately noticeable, it typically takes around four weeks for the drug to take effect. You will be reviewed regularly to check whether the drug and dose you are taking are effective. Your dose may be increased, or your treatment may be changed if you are not seeing any benefit, or if you are experiencing intolerable side-effects. Some people may start to feel better after a short period of time, but it is important not to stop taking your medication without talking to your health professionals as this can result in your depression coming back.  

The drugs used to manage depression vary in the way they work, but they all act by increasing the levels of neurotransmitters in the brain, for example serotonin or dopamine which are thought to boost mood. There are a number of effective medications that are prescribed for treating depression, the most commonly used drugs are called selective serotonin reuptake inhibitors (SSRIs), for example fluoxetine (Prozac) and paroxetine (Seroxat). Other drugs that are sometimes prescribed to treat moderate to severe depression include imipramine or amitriptyline (Triptafen), these two drugs can also be used in MS at lower doses to treat neuropathic (nerve) pain, even in the absence of depression.

Severe complicated depression

In rare circumstances, for example if you have had persistent and repeated episodes of severe depression which has resulted in severe self-neglect, or are thought to be a major risk to people close to you, the standard treatments described above may prove ineffective and you may be referred to specialist mental health services where you can receive a tailored programme of treatments in either an inpatient or outpatient setting.

If depression comes back

It is helpful to recognise if you are beginning to feel low again to try and help prevent further episodes, as for some people depression can recur. Approaches to help you might include keeping a diary, or there are also apps that can help you to monitor your social activity, exercise and sleep patterns - you might spot some changes that reflect your drop in mood. Using strategies that have helped you previously such as CBT could help you stay well.


  • National Institute for Health and Clinical Excellence. Depression in adults: recognition and management. London: NICE; 2009. Full guideline
  • National Institute for Health and Clinical Excellence. Depression in adults with a chronic physical health problem: recognition and management. London: NICE; 2009. Full guideline
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Last updated: 06 February 2017

Last reviewed: 26 September 2015
This page will be reviewed within three years